As a major research institution, the University of Missouri is subject to a broad range of environmental regulations. These requirements cover areas such as asbestos and lead management, air emissions, drinking water quality, stormwater control, spill prevention, and other activities that may impact air, water, or soil. Depending on the scope of a project, securing the necessary environmental permits from state agencies can take up to six months.

Ensuring compliance is a shared responsibility. Supervisors and Principal Investigators are expected to understand applicable regulations and implement procedures that maintain compliance. Students and employees must follow these procedures in their daily work.

Environmental Health & Safety (EHS) acts as the primary liaison between the university and regulatory agencies. EHS monitors regulatory developments, assists in the creation of campus policies, and supports departments in achieving compliance. In most cases, EHS also oversees and evaluates campus operations to ensure they meet all relevant environmental standards.