|1||Not known to consistently cause disease in healthy adults||Standard Microbiological Practices||None required||Open bench top sink required|
|2||Associated with human disease, hazard = percutaneous injury, ingestion, mucous membrane exposure||BSL-1 practice plus:
||Primary barriers = Class I or II BSCs or other physical containment devices used for all manipulations of agents that cause splashes or aerosols of infectious materials; PPE: laboratory coats, gloves, and face protection as needed||BSL-1 plus:
|3||Indigenous or exotic agents with potential for aerosol transmission; disease may have serious or lethal consequences||BSL-2 practice plus:
||Primary barriers = Class I or II BSCs or other physical containment devices used for all open manipulations of agents; PPE: protective lab clothing, gloves, and respiratory protection as needed||BSL-2 plus:
|4||Dangerous/exotic agents which pose high risk of life-threatening disease, aerosol-transmitted lab infections; or related agents with unknown risk of transmission||BSL-3 practice plus:
||Primary barriers = All procedures conducted in Class III BSCs or Class I or II BSCs in combination with full-body, air-supplied, positive pressure personnel suit||BSL-3 plus:
Note: There are no BSL-4 facilities at the University of Missouri.