Biological Laboratory Closure

Principal Investigators/Supervisors where biohazardous materials for rDNA or Biosafety Level 2 or 3 research activities are used, must complete a proper Biohazardous Material Laboratory Closure prior to terminating biohazardous material use. This will ensure proper transfer or disposal of all biohazardous materials, decontamination of any remaining contaminated items, accurate MU inventory records, and removal of biohazard signs/labels. EHS approval is required prior to release of laboratories for unrestricted use.

The following procedure provides steps for proper Biohazardous Material Laboratory Closure:

  • Contact the EHS Biological Safety Professional to discuss plans for changes or termination of activity (provide as much advanced notice as possible).
  • Properly sterilize, dispose or transfer all remaining biohazardous material when all biohazardous material work has been completed in your approved area. Shared storage areas must be carefully reviewed by departing and sharing researchers to identify biohazardous material ownership.
  • Decontaminate, clean and sanitize all potentially contaminated laboratory surfaces, equipment and fixtures (after a thorough survey to identify all rooms and equipment).
  • Contact EHS to arrange for pick-up and disposal of Biohazardous Unwanted Materials that have not been sterilized.
  • Schedule a closure survey with the EHS Biological Safety Professional and responsible Principal Investigator or Supervisor present. All labeled equipment, labware, fixtures, areas and rooms must be surveyed and de-labeled or de-posted by EHS before release for unrestricted use.
Note: Radiation Safety and Laboratory Safety have similar inactivating, decommissioning, transfer, and change notification requirements for use of radioactive material and hazardous chemical materials, respectively. Refer to the Radiation Safety Manual and Permitted Location Closeout Policy for specific requirements.